Which agency requires knowledge of proper handling, mixing, storage, and disposal of pesticides?

The correct answer is the Environmental Protection Agency (EPA). The EPA is a federal agency responsible for regulating and ensuring the safe use of pesticides in the United States. It establishes guidelines and regulations concerning the proper handling, mixing, storage, and disposal of pesticides to protect human health and the environment. This includes requirements for labeling, usage practices, and training for individuals who apply pesticides, which directly relates to the necessary knowledge in the aerial application of these substances.

In contrast, the other agencies focus on different aspects. The Occupational Safety and Health Administration (OSHA) is primarily concerned with workplace safety and health regulations but does not specifically focus on pesticides. The United States Department of Agriculture (USDA) deals with agricultural policies and practices and may involve pesticides in a broader context, but it does not have the specific regulatory authority for their safe handling and use like the EPA. The Federal Aviation Administration (FAA) oversees civil aviation and focuses on air travel safety and aircraft operations, having no direct jurisdiction over pesticide handling or applications.