Which scenario would have little effect on the safety and effectiveness of an application?

The scenario involving moving the operation to a different mixing-loading location is considered to have little effect on the safety and effectiveness of an application. This is because, as long as the new location maintains appropriate safety standards and is still compliant with regulations concerning handling chemicals, the actual site change may not significantly impact the aerial application process.

For effective application, the main concerns involve the environmental conditions, such as wind intensity, which can directly affect the drift and deposition of the chemicals. Additionally, ensuring the safety of field workers by delaying application until they leave is crucial for compliance and safety, but it does not pertain to the effectiveness of the application itself. Lastly, a buffer area is essential to protect sensitive areas from unintended exposure to applied substances, which can influence both safety and effectiveness. Therefore, of all the scenarios presented, relocating the mixing-loading site remains the least likely to alter application outcomes.